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Opana ER and Oxycodone both are opioid analgesics used for the treatment of moderate to acute ongoing pain. The only few difference between these drugs are:

When it comes to strength and potency, Opana ER is much stronger than Oxycodone. The most crucial difference between these drugs is that Opana can be used before surgery for sedation and anxiety. However, Oxycodone is not meant for that purpose and typically is used for relieving moderate to severe pain.