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This is due to both the parts of the drug – Hydrocodone and Paracetamol. The intake of the dosage is scheduled in such a way that the blood level of these two drugs is strong enough to provide constant pain relief as the body of the patient breaks down and eliminates them. The half-life of the drug depends on the half-life of both Hydrocodone and Paracetamol, which is around three hours and four hours, respectively.